Adipose-Derived Mesenchymal Stem Cells Partially Compensating the Neurodegenerative Signs at The Behavioral, Physiological, and Molecular Levels in AD Rat Model

Alzheimer's disease (AD) is the most common form of dementia. Due to multifaceted nature AD pathology and limited understanding its etiology, difficult be treated with currently available pharmaceuticals. Recent studies suggest that transplantation mesenchymal stem cells might have therapeutic potential on several neurodegenerative disorders. In addition, it can ameliorate neuropathological deficits physiological disorders in AD. The current study aims evaluate effect adipose-derived (ADMSCs) rat model after induction AlCl3.   After phase, labeled ADMSCs been injected intravenously. Open-field behavioral tests were conducted, serum ?-amyloid levels, cholinesterase activity, brain antioxidant status evaluated. Besides, expression apoptotic necrotic markers was quantified via RT-qPCR tissues. Histopathological alterations examined as well. Signs dementia manifested by recorded rats, accumulation blood, reduced activity both tissues had at end phase. All these partially/fully compensated administration ADMSCs, which proved their ability penetrate blood-brain barrier home molecular mechanism underlying seems correlated reduction neurodegeneration upregulating anti-apoptotic marker (Bcl2) downregulating pro-apoptotic (p53 Bax) factor (Tnfa) simultaneously.